OBAT KANKER PAYUDARA: APA ITU NIGELLA SATIVA

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Rabu, 12 Agustus 2009

Kumpulan Riset Ilmiah Terhadap Habbatussauda

HABBATUSSAUDA OBAT SEGALA MACAM PENYAKIT KECUALI KEMATIAN (HR. BUKHARI MUSLIM) MADU OBAT YANG MENYEMBUHKAN BAGI MANUSIA (QS:AN-NAHL: 69) UNTUK PEMESANAN HUBUNGI BIN MUHSIN HP:085227044550 / 021-91913103 EMAIL /YM : binmuhsin_group@yahoo.co.id friendster: ujang_bmz@yahoo.co.id
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Rabu, 22 Juli 2009 14:44 Dokter Insan

nigella1-125_125 1. Title : Studies on the antimicrobial activity of Nigella sativa seed (black cumin).
Author : Hanafy, M S : Hatem, M E
Citation : J-Ethnopharmacol. September 1991; 34(2-3): 275-8
• Riset thd aktifitas antibiotika Habbatussauda terhadap bakteri gram positif Staphylococcus aureus, bakteri gram negatif Pseudomonas aeruginosa dan E. coli.
2. The invitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L.
Worthen DR, Ghosheh OA, Crooks PA.
Natural Products Chemistry Laboratory, Tobacco and Health Research Institute, Lexington, KY 40536, USA.
Anticancer Res 1998 May-Jun 18(3A):1527-32
• Penelitian efek antikanker dari serbuk, minyak dan komponen Habbatussauda terhadap beberapa Multi Drug Resisten (MDR) human tumor cell lines. Hasilnya menunjukkan Habbatussauda memiliki efek cytotoxic terhadap beberapa type human tumor cells.
3. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa
M. S. Al-Ghamdi
Department of Pharmacology, King Faisal University, College of Medicine, PO Box 2114, Dammam 31451, Saudi Arabia, 27 January 2001
• Riset yang membuktikan bahwa habbatussauda memiliki efek antiradang, analgesik (anti nyeri), dan turun panas.
4. A new and novel treatment of opioid dependence: Nigella sativa 500 mg.
Sangi S, Ahmed SP, Channa MA, Ashfaq M, Mastoi SM.
Department of Pharmacology, Fatima Jinnah Dental College, Karachi
J Ayub Med Coll Abbottabad. 2008 Apr-Jun.
• Treatment habbatussauda 500 mg longterm/jangka panjang, mengurangi ketergantungan terhadap narkoba opioid.
5. Pharmacological and toxicological properties of Nigella sativa.
Ali BH, Blunden G.
Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem 81999, Saudi Arabia.
Phytother Res. 2003 Apr;17(4):299-305.
• Penelitian yang menunjukkan efek farmakologi habbatussauda dalam melindungi ginjal dan hepar (liver). Penelitian juga mengungkap khasiat antiradang, analgesik, antipiretik, antimikroba dan antikanker dari serbuk maupun minyak habbatussauda. Minyak Habbatussauda diteliti dapat menurunkan tekanan darah & meningkatkan respirasi. Uji pada tikus menunjukkan habbat dapat meningkatkan Hb dan komponen sel darah. Serta mengurangi konsentrasi kolesterol, trigliserid dan glukosa dalam plasma darah. Riset ini menunjukkan juga bahwa toxicitas habbatussauda sangat rendah. Dan tidak berefek samping ke liver maupun ginjal.
6. Thymoquinone protects dopaminergic neurons against MPP+ and rotenone.
Radad K, Moldzio R, Taha M, Rausch WD.
Pathology Department, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt
• Riset awal dan baru pertama kali yang menunjukkan potensi thymoquinon (yang berada di dalam habbatusauda) melindungi neuron dopaminergik primer menghadapi MPP (+) dan rotenon. Hal ini bermanfaat bagi penderita Parkinson.
7. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension.
Dehkordi FR, Kamkhah AF.
Department of Internal Medicine and Cardiology and Medicinal Plant Research Center, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Fundam Clin Pharmacol. 2008 Aug;22(4):447-52
• Riset yang membuktikan bahwa dengan penggunaan ekstrak habbatussauda 200 mg sehari 2 kali, dapat menurunkan tekanan darah tinggi ringan dalam pemakaian 2 bulan.
8. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract.
Dirjomuljono M, Kristyono I, Tjandrawinata RR, Nofiarny D.
Department of Ear, Nose, Throat, Faculty of Medicine, University of Airlangga/Dr. Soetomo General Hospital, Surabaya, Jakarta, Indonesia.
Int J Clin Pharmacol Ther. 2008 Jun;46(6):295-306
• Study yang membuktikan bahwa habbatussauda 360 mg yang digabung dengan meniran 50 mg dan dikonsumsi 3 kali sehari, dapat membantu terapi tonsilopharingitis akut (amandel).
9. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures.
Akhondian J, Parsa A, Rakhshande H.
Department of Pediatrics and Pediatric Neurology, Mashhad University of Medical Sciences, Ghaem Medical Center, Mashhad, Iran.
Med Sci Monit. 2007 Dec;13(12):CR555-9.
• Penelitian membuktikan bahwa ekstrak air dari habbatussauda dengan dosis 40 mg/kg BB/8 jam, dapat memberikan efek antiepileptik pada penderita epilepsi dengan refractory seizures.
10. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients.
Boskabady MH, Javan H, Sajady M, Rakhshandeh H.
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad 91735, Iran
Fundam Clin Pharmacol. 2008 Feb;22(1):105
• Pada penelitian ini dibuktikan bahwa Habbatussauda dapat disarankan sebagai terapi propilaksis pada penderita asma. Dosis yang dipakai adalah 15 mL/kg dari 0,1 g% boiled extract.
11. Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells.
Norwood AA, Tan M, May M, Tucci M, Benghuzzi H.
School of Health Related Professions, University of Mississippi Medical Center Jackson, Mississippi 39216, USA.
Biomed Sci Instrum. 2006;42:350-6.
• Penelitian ini menunjukkan bahwa efek kemoterapi pada sel kanker dari Habbatussauda (Thymoquinon) setara dengan 5-fluoruracil.
12. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines.
Rooney S, Ryan MF.
Department of Zoology, University College Dublin, Belfield, Dublin 4, Ireland.
Anticancer Res. 2005 May-Jun;25(3B):2199-204
• Penelitian ini menunjukkan efek alpha hederin dan thymoquinone yang merupakan kandungan dari habbatussauda terhadap sel kanker A549 Karsinoma Paru, HEp-2 (larynx epidermoid carcinoma), HT-29 (colon adenocarcinoma) and MIA PaCa-2 (pancreas carcinoma).
13. The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions.
El-Dakhakhny M, Mady N, Lembert N, Ammon HP.
Planta Med. 2002 May;68(5):465-6
• Penelitian ini menerangkan kemungkinan besar bahwa efek hypoglikemik dari habbatussauda dimediasi oleh aktifitas di luar pankreas dan bukan di pankreas.
14. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters
K. M. Fararha, Y. Atojib, Y. Shimizua, T. Shiinaa, H. Nikamia and T.
Department of Physiology and Pathogenetic Veterinary Sciences, The United Graduate School, Gifu University, 1-1 Yanagido, 501-1193, Gifu, Japan
Department of Anatomy, The United Graduate School, Gifu University, 501-1193, Gifu, Japan
Received 12 March 2004.
Available online 2 June 2004.
• Penelitian ini menunjukkan bahwa efek hypoglikemik dari habbatussauda adalah dengan menurunkan hepatic gluconeogenesis. Sedangkan efek imunopotensiasi nya adalah melalui stimulasi aktifitas fagosit dari makrofag dan aktifitas lymposit.
15. Effect of Nigella sativa Volatile Oil on Jurkat T Cell Leukemia Polypeptides
Nabil Hailat, Ziad Bataineh, Shawkat Lafi, Essam Raweily, Mahmoud Aqel, Mohamad Al-Katib and Sam Hanash
Molecular Pathology Laboratory, Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology (Irbid)
Department of Anatomy, Jordan University of Science and Technology (Irbid)
Department of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology (Irbid)
Department of Anatomy, University of Jordan (Amman), Jordan
Department of Microbiology, University of Jordan (Amman), Jordan
Department of Pediatric Haematology, University of Michigan, Ann Arbor, MI, USA
Assistant Professor of Immunopathology, Head of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid-Jordan
Pharmaceutical Biology
1995, Vol. 33, No. 1, Pages 16-20 , DOI 10.3109/13880209509088141
• Penelitian ini mempelajari efek dari Habbatussauda terhadap Jurkat T Cell leukemia.
16. Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells.
Farah,-I-O; Begum,-R-A
Biomed-Sci-Instrum. 2003; 39: 359-64.
• Penelitian ini menyimpulkan bahwa habbatussauda, baik sendiri maupun digabung dgn antioxidative stress ditemukan efektif secara invitro untuk menghambat pertumbuhan sel kanker payudara MCF-7. Hal ini membuka kemungkinan bagi digunakannya habbatusauda sebagai bahan terapi maupun pencegah kanker.
17. Androgen Receptor- and E2F-1-Targeted Thymoquinone Therapy for Hormone-Refractory Prostate Cancer
Ahmed O. Kaseb, Kannagi Chinnakannu, Di Chen, Arun Sivanandam, Sheela Tejwani, Mani Menon, Q. Ping Dou and G. Prem-Veer Reddy
Department of Hematology/Oncology and Vattikuti Urology Institute, Henry Ford Hospital; Barbara Ann Karmanos Cancer Institute; and Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan
Requests for reprints: G. Prem-Veer Reddy, Vattikuti Urology Institute, Henry Ford Health System, One Ford Place, 2D, Detroit, MI 458202. Phone: 313-874-5991;
American Association for Cancer Research; Cancer Res 2007;67(16):7782-8
• Penelitian ini menyimpulkan bahwa thymoquinone dapat digunakan sbg bahan terapi bagi kanker prostat.
18. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
1. Tingfang Yi1,
2. Sung-Gook Cho1,
3. Zhengfang Yi3,
4. Xiufeng Pang13,
5. Melissa Rodriguez1,
6. Ying Wang1,
7. Gautam Sethi2,
8. Bharat B. Aggarwal2 and
9. Mingyao Liu1
Accepted April 18, 2008. Received February 4, 2008. Revision received April 12, 2008.
Grant support: National Cancer Institute/NIH grant 1R01CA106479 . American Association for Cancer Research
• Penelitian ini menunjukkan bahwa thymoquinone menghambat proses angiogenesis dari tumor dan menghambat pertumbuhan tumor. Saran dari peneliti bahwa habbatussauda (Thymoquinone) bisa menjadi kandidat yang potensial bagi terapi kanker di masa depan.

diambil dari seminar dr. Insan Agung Nugroho pada acara Gathering Nasional, 12 Juli 2009 di gedung Daarul Hajj-Daarut Tauhid Bandung

Terakhir Diperbaharui ( Selasa, 04 Agustus 2009 14:01 )

Rabu, 28 Mei 2008

Clinical Data on Black Seed Herb

HABBATUSSAUDA OBAT SEGALA MACAM PENYAKIT KECUALI KEMATIAN (HR. BUKHARI MUSLIM) UNTUK PEMESANAN HUBUNGI BIN MUHSIN HP:085227044550 EMAIL: binmuhsin_group@yahoo.co.id friendster: ujang_bmz@yahoo.co.id
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Clinical Data on Black Seed Herb

Black seed is used for treating gastrointestinal conditions including gas, colic, diarrhea, dysentery, constipation and haemorrhoids. It is also used for respiratory conditions, including asthma, allergies, cough, bronchitis, emphysema, flu and congestion. Additionally, it is used as an antihypertensive, immunoprotectant, anticancer agent, and vermifuge. It is used orally for women's health: including as a contraceptive, for stimulation of menstruation, and increasing milk flow.

In allergic conditions, black seed may have antihistamine effects. Black seed is thought to have immunoprotectant effects. Preliminary evidence suggests it may help minimize chemotherapy-induced decreases in hemoglobin and leukocyte counts. Black seed may be beneficial as an anticancer agent. According to preliminary studies, black seed may inhibit stomach tumors, carcinoma, and Ehrlich ascites carcinoma.

Black seed is reported to have been used for over 2000 years. Recordings mention it as far back as 1400 years. Black seed was found in the tomb of King Tutankhamen.

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Published Clinical Studies
Black Seed Herb

The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production.(click here to view report)

Neuropharmacological activity of Nigella sativa L. extracts.(Click here to view)

Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis.(Click here to view)

Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress.(Click here to view)

Delayed apoptosis upon the treatment of Hep-2 cells with black seed.(Click here to view)

Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells.(Click here to view)

Protective effect of Nigella sativa seeds against carbon tetrachloride-induced liver damage.(Click here to view)

Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases.(Click here to view)

The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production.

Mahmood MS, Gilani AH, Khwaja A, Rashid A, Ashfaq MK.

Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan.

The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide (NO) production by murine macrophages was studied. Murine peritoneal macrophages were pre-incubated with the extract and then activated with Escherichia coli lipopolysaccharride. NO production was measured after 24 hours by spectrophotometry. The plant extract caused a dose-dependent decrease in NO production. Dialyzed preparation of the extract did not affect NO production. However, the boiled fraction of the extract resulted in a dose-dependent inhibition of NO apparently comparable to that of the whole extract. These results indicate that the aqueous extract of N. sativa seeds exhibits an inhibitory effect on nitric oxide production by murine macrophages and the active component(s) is/are non-protein in nature. In view of the fact that nitric oxide is a pro-inflammatory mediator, this study validates the traditional use of the Nigella sativa seeds for the treatment of rheumatism. Copyright 2003 John Wiley & Sons, Ltd.

PMID: 13680825 [PubMed - indexed for MEDLINE]

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Neuropharmacological activity of Nigella sativa L. extracts.

Al-Naggar TB, Gomez-Serranillos MP, Carretero ME, Villar AM.

Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Pharmacological studies have been conducted on the aqueous and methanol extracts of defatted Nigella sativa L. seeds to evaluate their effects on the central nervous system (CNS) and on analgesic activity. The observations suggest that the two extracts of Nigella sativa possesses a potent CNS and analgesic activity (depressant action especially in the case of the methanolic extract).

PMID: 12902052 [PubMed - indexed for MEDLINE]

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Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis.

Salim EI, Fukushima S.

Laboratory of Experimental and Molecular Carcinogenesis, Department of Zoology, Faculty of Science, Tanta University, Tanta 31527-Egypt.

Chemopreventive effects of orally administered Nigella sativa oil on the induction and development of 1,2-dimethylhydrazine-induced aberrant crypt foci (ACF), putative preneoplastic lesions for colon cancer, were investigated in Fischer 344 rats. Starting at 6 wk of age, 45 male rats (groups 1-3) were subcutaneously injected with DMH once a week for 3 wk. Group 1 (15 rats) served as a carcinogen control group without N. sativa administration. Group 2 or 3 (15 rats each) were given the oil in the postinitiation stage or in the initiation stage, respectively. Animals of group 4 (11 rats) were injected with 0.9% saline and received N. sativa oil from the beginning until the termination. At sacrifice, 14 wk after the start, the total numbers of ACF as well as those with at least four crypts were significantly reduced in group 2 (P <>

PMID: 12881014 [PubMed - in process]

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Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress.

Khan N, Sharma S, Sultana S.

Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi 110 062, India.

Potassium bromate (KBrO3) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO3-mediated renal oxidative stress, toxicity and tumor promotion response in rats. KBrO3 (125 mg/kg body weight, intraperitoneally) enhances lipid peroxidation, gamma-glutamyl transpeptidase, hydrogen peroxide and xanthine oxidase with reduction in the activities of renal antioxidant enzymes and renal glutathione content. A marked increase in blood urea nitrogen and serum creatinine has also been observed. KBrO3 treatment also enhances ornithine decarboxylase (ODC) activity and [3H] thymidine incorporation into renal DNA. Prophylaxis of rats orally with Nigella sativa extract (50 mg/kg body weight and 100 mg/kg body weight) resulted in a significant decrease in renal microsomal lipid peroxidation (P <>

PMID: 12755470 [PubMed - indexed for MEDLINE]

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Delayed apoptosis upon the treatment of Hep-2 cells with black seed.

Corder C, Benghuzzi H, Tucci M, Cason Z.

University of Mississippi Medical Center, Jackson, MS 39216, USA.

Nigella sativa (Black seed, BS) has been used to promote health and fight disease for centuries. The objectives of this investigation were: (1) to study whether agents such as cortisol and LPS alone or in combination induce cellular (Hep-2, laryngeal carcinoma) damage with time in culture (24, 48, and 72 hours) using apoptosis as a marker, (2) to determine if an immune stimulant such as BS, can protect Hep-2 cells from insult and ultimately thwart the programmed cells death mechanism. A total of 54 Hep-2 cell/tubes (50,000 cells per tube) were divided into six equal groups. Group one served as untreated control, while groups 2-6 were treated with either cortisol (10 ng/ml), LPS (10 micrograms/ml), BS (25 micrograms/ml), or a combination of LPS and cortisol and cortisol plus LPS plus BS, respectively. At the end of each phase the cells were harvested, heat fixed and stained with H&E to evaluate morphological changes. Immunohistochemistry, using antibodies against caspace-3 to evaluate cells undergoing apoptosis was conducted in all groups. The results of this study showed evidence of cells undergoing apoptosis at different magnitudes in all groups. However, the most dramatic change was seen in groups containing cortisol and LPS alone or in combination. This was supported by the fact that there were several adaptive responses observed in all phases. In addition, the exposure of BS to cells pretreated with cortisol and LPS showed evidence of protection against the progressive apoptosis.

PMID: 12724921 [PubMed - indexed for MEDLINE]

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Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells.

Farah IO, Begum RA.

Jackson State University, Jackson, MS 39217, USA.

N. Sativa L., an oriental spice, has long been used as a natural medicine for treatment of many acute as well as chronic conditions. It has been used in the treatment of diabetes, hypertension, and dermatological conditions. There has been very few studies on the effects of N. Sativa as cancer prevention/therapy. Our objective therefore, was to expose MCF-7 breast cancer cells to aqueous and alcohol extracts and in combination with H2O2 as an oxidative stressor. Measurement of cell survival under various concentrations and combinations was conducted using standard cell culture techniques, exposure protocols in 96 well plates and Fluoro-spectrosphotometry. Following cellular growth to 90% confluency, exposure to water (WE) and ethanol (AE) extracts of N. sativa and H2O2 was performed. Toxicity index (LC50) was calculated from percent survival using regression analysis. Results showed that the alcohol extract and its combinations were able to completely inactivate the MCF-7 cells (LC50 ranged from 377.16-573.79 in descending potency for H2O2 + AE, AE and Mix of WE and AE). H2O2 alone effectively inactivated MCF-7 cells (LC50 = 460.94). The least effective combinations in descending potency were WE + H2O2, WE + AE + H2O2, and WE (LC50 were 725.79, 765.94, and 940.5 respectively. Combinations other than AE + H2O2 showed possible interactions, which lead to reduction in their potency. In conclusion, N. Sativa alone or in combination with oxidative stress were found to be effective in vitro in inactivating MCF-7 breast cancer cells, unveiling opportunities for promising results in the field of prevention and treatment of cancer.

PMID: 12724920 [PubMed - indexed for MEDLINE]

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Protective effect of Nigella sativa seeds against carbon tetrachloride-induced liver damage.

Al-Ghamdi MS.

Department of Pharmacology, College of Medicine, King Faisal University, Dammam, Saudi Arabia. mghamdi@Dammam.kfu.edu.sa

It has been reported that Nigella sativa oil possesses hepatoprotective effects in some models of liver toxicity. However, it is N. sativa seeds that are used in the treatment of liver ailments in folk medicine rather than its oil. Therefore, the aim of this study was to investigate the effect of the aqueous suspension of N. sativa on carbon tetrachloride (CCL4)-induced liver damage. Aqueous suspension of the seeds was given orally at two dose levels (250 mg/kg and 500 mg/kg) for five days. CCL4 (250 microl/kg intraperitoneally / day in olive oil) was given to the experimental group on days 4 and 5, while the control group was only treated with the vehicles. Animals treated with CCL4 showed remarkable centrilobular fatty changes and moderate inflammatory infiltrate in the form of neutrophil and mononuclear cells when compared to the controls. This effect was significantly decreased in animals pretreated with N. sativa. Histopathological or biochemical changes were not evident following administration of N. sativa alone. Serum levels of aspartic transaminase (AST), and L-alanine aminotransferase (ALT) were slightly decreased while lactate dehydrogenase (LDH) was significantly increased in animals treated with CCL4 when compared to the control group. LDH was restored to normal but ALT and AST levels were increased in animals pretreated with N. sativa. In conclusion, N. sativa seeds appeared to be safe and possibly protective against CCL4-induced hepatotoxicity. However, further studies may still be needed prior to supporting its use in folk medicine for hepatic diseases.

PMID: 14696675 [PubMed - in process]

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Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases.

Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, Kiesewetter H.

Humboldt University, Berlin, School of Medicine, Institute for Transfusion Medicine, Charite University Hospital, Berlin, Germany.

Nigella sativa (black seed) is an important medicinal herb. In many Arabian, Asian and African countries, black seed oil is used as a natural remedy for a wide range of diseases, including various allergies. The plant's mechanism of action is still largely unknown. Due to the lack of study data on its efficacy in allergies, four studies on the clinical efficacy of Nigella sativa in allergic diseases are presented. In these studies, a total of 152 patients with allergic diseases (allergic rhinitis, bronchial asthma, atopic eczema) were treated with Nigella sativa oil, given in capsules at a dose of 40 to 80 mg/kg/day. The patients scored the subjective severity of target symptoms using a predefined scale. The following laboratory parameters were investigated: IgE, eosinophil count, endogenous cortisol in plasma and urine, ACTH, triglycerides, total cholesterol, LDL and HDL cholesterol and lymphocyte subpopulations. The score of subjective feeling decreased over the course of treatment with black seed oil in all four studies. A slight decrease in plasma triglycerides and a discrete increase in HDL cholesterol occurred while the lymphocyte subpopulations, endogenous cortisol levels and ACTH release remained unchanged. Black seed oil therefore proved to be an effective adjuvant for the treatment of allergic diseases. Copyright 2003 John Wiley & Sons, Ltd.

PMID: 14669258 [PubMed - in process]

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References

Hanafy MS, Hatem ME. Studies on the antimicrobial activity of Black seed seed (black cumin). J Ethnopharmacol 1991;34(2-3):275-8.

The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

Akhtar MS, et al. Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. JPMA J Pak Med Assoc 1991 Aug;41(8)185-7.

Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31(3):283-9.

Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39(1):59-62.

Aqel M, Shaheen R. Effects of the volatile oil of Black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52(1):23-6.

Nagi MN, Alam K, Badary OA, et al. Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Biochem Mol Biol Int 1999;47(1):153-9.

Chakravarty N. Inhibition of histamine release from mast cells by nigellone. Ann Allergy 1993;70(3):237-42.

Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of blackseed, Black seed L. Anticancer Res 1998;18(3A):1527-32.

Daba MH, Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol Lett 1998;95(1):23-9.

Salomi NJ, Nair SC, Jayawardhanan KK, et al. Antitumour principles from Black seed seeds. Cancer Lett 1992;63(1):41-6.

Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Black seed and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995;61(1):33-6.

Haq A, Abdullatif M, Lobo PI, et al. Black seed: effect on human lymphocytes and polymorphonuclear leukocyte phagocytic activity. Immunopharmacology 1995;30(2):147-55.

Badary OA, Al-Shabanah OA, Nagi MN, et al. Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Eur J Cancer Prev 1999;8(5):435-40.

Medenica RD. Use of Black seed to increase immune function. U.S. Patent 5,482,711, issued January 9, 1996. Obtained from US Patent and Trademark Ofc on April 12, 2000. www.uspto.gov/patft/index.htm.

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Increases immune function.
~ U.S. Patents Sections, Antiviral Agents Bulletin #5,482,711

Black seed stimulates bone marrow and immune cells and raises the interferon production, protects normal cells against cell destroying effects of viruses, destroys tumor cells and raises the number of anti-bodies producing B cells.
~ Cancer Immuno-biology Laboratory ,South Carolina

Black seed contains valuable unsaturated fatty acids, for example Linoleic and Gammalinolen acids get into the organism. By that it possible to reach a synthesis of important immune regulating substances derived as from Prostaglandin E1. Linoleic acid stabilizes the cell membranes and Prostaglandin has the effect of inhibiting inflammation. By that the immune reactions are stopped which cause the illnesses and which otherwise could be the start of many chronic illnesses like acne and hayfever right up to cancer.
~ Dr. Peter Schleicher Immunologist, Munich, Germany

Black seed proves to have an ant histamine, ant-oxidant, anti-biotic, anti-mycotic and broncho-dilating effect.
~ Study of Black seed oil on humans, American Scientists

Black seed is truly a remarkable herb that has been used for over 3000 years. It contains over 100 valuable components. It is a significant source of essential fatty acids, proteins, carbohydrates and other vitamins and minerals. " The seeds are also rich in sterols, especially beta-sitosterol, which is known to have anticarcinogenic activity".
~ Dr. Michael Tierra L.AC. O.M.D

Black seed tests prove to be genuine universal remedy.
~ Pharmaceutical newspaper, Wissenschaftlicher Text

Black seed is a valuable source of protein, carbohydrates, essential fatty acids, vitamins A, B1, B2, C and niacin as well as minerals such as calcium, potassium, iron, magnesium, selenium, magnesium and zinc.
~ Phytochemicals of Nigella sativa seeds. Food Chemistry

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